Jack Parker, 15, was last seen about 2.30pm on Tuesday on Bodmin Road, Tyldesley.
Jack is described as white, 6ft 3ins tall, of slim build with a shaved head and brown eyes.
He was last seen wearing black Nike tracksuit bottoms, a navy blue ribbed coat, black Adidas torsion trainers with a red Adidas logo on the tongue.
A Greater Manchester Police spokesman said that officers are becoming increasingly concerned for Jack and want to make sure he is safe and well.
Anyone with information about Jack’s whereabouts is asked to contact police on 0161 856 7122.